Aloxi web

Half-Life & Metabolism

ALOXI^® BINDS STRONG, LASTS LONG
All 5-HT₃ Receptor Antagonists Are NOT the Same

LONG HALF-LIFE¹

Longer half-life than other 5-HT3 receptor antagonists.^1-4
The extended half-life of ALOXI does not lead to an increase in the duration of adverse reactions.^5,6

ALOXI - Plasma Half-Life

^*Half-life reported for hydrodolasetron, the active metabolite of dolasetron.

CYP2D6 PATHWAY INVOLVED IN ALOXI METABOLISM¹

ALOXI - Pharmacokinetics

Clinical pharmacokinetic parameters are not significantly different between poor and extensive metabolizers of CYP2D6 substrates.¹

References

NCCN® Practice Guidelines in Oncology - v.1.2005: Antiemesis. National Comprehensive Cancer Network. Available at: http://www.nccn.org/professionals/physician_gls/PDF/antiemesis.pdf. Accessed February 24, 2005.

ALOXI (palonosetron HCl) injection full prescribing information.

Anzemet® (dolasetron mesylate) full prescribing information.

Zofran® (Ondansetron hydrochloride) full prescribing information.

Kytril® (granisetron hydrochloride) full prescribing information.

Data on file.

Gralla R, Lichinitser M, Van der Vegt, S, et al. Palonosetron improves prevention of chemotherapy-induced nausea and vomiting following moderately emetogenic chemotherapy: results of a double-blind randomized phase III trial comparing single doses of palonosetron with ondansetron. Ann Oncol. 2003;14:1570-1577.

During initial and repeat courses of chemotherapy, ALOXI helps prevent and control nausea and vomiting the day following chemotherapy that is highly likely to cause nausea and vomiting, and for up to 5 days following chemotherapy that is likely to cause nausea and vomiting. The most frequent side effects of ALOXI include headache and constipation. If you have or may develop significant heart rhythm changes, talk with your healthcare professional before receiving ALOXI.

ALOXI is available by prescription only. Please see the important product information for ALOXI for more information.

This site does not contain everything that is known about ALOXI. If you would like to know more, talk to your healthcare professional.