About chemotherapy-induced nausea and vomiting (CINV)

If you are starting chemotherapy, you are probably experiencing many feelings, both emotional and physical. Unfortunately, CINV might be among them.

Chemotherapy is administered in order to hopefully eliminate cancer cells in the body. Very often, healthy cells may be damaged or destroyed, as well. These chemotherapy drugs activate chemical signals in the body that send a message to the brain that a toxin is present. This may result in nausea and vomiting. One of the most common chemical signals of nausea or vomiting from chemotherapy is the release of serotonin from your body. Serotonin may attach to receptors known as 5-hydroxytryptamine-3 (5-HT3) receptors, sending off signals to the brain. When the signals reach the brain, CINV may result.

  • Nausea is defined as the urge to vomit; it may or may not result in vomiting

  • Vomiting is the expulsion of stomach contents through the mouth

CINV may be prevented

The good news is that you can take measures to keep CINV at bay. There are medicines to help keep you from feeling sick after receiving chemotherapy.

Indication in Adults

  • ALOXI® injection 0.25 mg/5 mL is used in adults to help prevent nausea and vomiting on the day of chemotherapy that is highly likely to cause nausea and vomiting, and up to 5 days following chemotherapy that is moderately likely to cause nausea and vomiting.

Indication in Pediatrics

  • ALOXI injection 20 mcg/kg (max 1.5 mg) is used in children 1 month old to less than 17 years of age to help prevent nausea and vomiting on the day of chemotherapy that is moderately or highly likely to cause nausea and vomiting.

Important Safety Information

  • ALOXI can cause allergic reactions that can be serious. Tell your doctor or nurse right away if you have any of these following symptoms of a serious allergic reaction: hives, swelling of the face, trouble breathing and chest pain

  • The most common side effects of ALOXI in adults are headache and constipation

  • Tell your doctor or nurse if you are taking other medications or if you are pregnant or breastfeeding or plan to become pregnant or breastfeed

For more information about ALOXI, talk to your doctor or see full Prescribing Information.

ALOXI is available by prescription only.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare professional. All decisions regarding patient care must be made with a healthcare professional, considering the unique characteristics of the patient.

This site is intended for residents of the United States only. Any products discussed herein may have different product labeling in different countries.

This website contains information relating to various medical conditions and treatment. Such information is provided for educational purposes only and is not meant to be a substitute for the advice of a physician or other healthcare professionals. You should not use this information for diagnosing a health problem or disease. In order for you to make intelligent healthcare decisions, you should always consult with a physician or other healthcare provider for you, or your loved ones', personal medical needs. All quotes included in this website represent the individual experience of some doctors, some patients, and their caregivers. Individual responses to treatment may vary. Actual identities have been changed to protect individual privacy.

To report SUSPECTED ADVERSE REACTIONS, contact EISAI at 1-888-422-4743 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

ALOXI® is a registered trademark of Helsinn Healthcare SA, Switzerland, used under license.
Distributed by Eisai Inc. under license of Helsinn Healthcare SA, Switzerland. Marketed by Eisai Inc. and Helsinn Therapeutics (U.S.), Inc.
© 2016 Eisai Inc. All rights reserved. ALOX-US0149 07/16

Important Safety Information Expand

Indication in Adults

  • ALOXI® injection 0.25 mg/5 mL is used in adults to help prevent nausea and vomiting on the day of chemotherapy that is highly likely to cause nausea and vomiting, and up to 5 days following chemotherapy that is moderately likely to cause nausea and vomiting.

Indication in Pediatrics

  • ALOXI injection 20 mcg/kg (max 1.5 mg) is used in children 1 month old to less than 17 years of age to help prevent nausea and vomiting on the day of chemotherapy that is moderately or highly likely to cause nausea and vomiting.

Important Safety Information

  • ALOXI can cause allergic reactions that can be serious. Tell your doctor or nurse right away if you have any of these following symptoms of a serious allergic reaction: hives, swelling of the face, trouble breathing and chest pain

  • The most common side effects of ALOXI in adults are headache and constipation

  • Tell your doctor or nurse if you are taking other medications or if you are pregnant or breastfeeding or plan to become pregnant or breastfeed

For more information about ALOXI, talk to your doctor or see full Prescribing Information.

ALOXI is available by prescription only.

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