Preventing Chemotherapy-Induced Nausea and Vomiting

ALOXI (palonosetron HCI injection) is an anti-nausea medication also known as an antiemetic. In adults, ALOXI is used to help prevent symptoms of chemotherapy-induced nausea and vomiting (CINV) in a single intravenous (IV) dose by blocking the effects of serotonin.

Depending on the type of chemotherapy you get, your chance of experiencing CINV on the same day, known as acute CINV, can be very high. You may also experience delayed CINV in the days following your treatment. ALOXI is used to prevent both acute and delayed CINV in patients receiving moderately emetogenic chemotherapy and acute CINV in patients receiving highly emetogenic chemotherapy.

If you experience CINV during one chemotherapy cycle, you are more likely to experience CINV again during a later cycle. Speak to your health care team on the importance of trying to prevent these symptoms before they start.

Powerful CINV prevention in a single dose

ALOXI is given as a single intravenous (IV) injection administered by a health care professional about 30 minutes before the start of chemotherapy treatment. The single ALOXI injection is likely to be given through the same IV line as your chemotherapy.

From the first cycle, ALOXI can help prevent nausea and vomiting for:

  • One day following chemotherapy that is highly likely to cause nausea and vomiting
  • Up to five days following chemotherapy that is moderately likely to cause nausea and vomiting

ALOXI for CINV Prevention


Your doctor or nurse will help you determine if using ALOXI should be part of your chemotherapy-induced nausea and vomiting prevention plan. Talk to your doctor and do not take ALOXI if you are allergic to any of its ingredients. The ingredients in ALOXI are:

Active ingredient: Palonosetron hydrochloride
Inactive ingredients: mannitol, disodium edetate, and citrate buffer in water

Potential side effects of ALOXI include headache and constipation. For a complete list of side effects Please read the Full Product Information and discuss it with your doctor or health care professional.

Indication in Adults

  • ALOXI injection 0.25 mg/5 mL is used in adults to help prevent nausea and vomiting on the day of chemotherapy that is highly likely to cause nausea and vomiting, and up to 5 days following chemotherapy that is moderately likely to cause nausea and vomiting.

Important Safety Information

  • ALOXI can cause allergic reactions that can be serious. Tell your doctor or nurse right away if you have any of these following symptoms of a serious allergic reaction: hives, swelling of the face, trouble breathing and chest pain
  • The most common side effects of ALOXI in adults are headache and constipation
  • Tell your doctor or nurse if you are taking other medications or if you are pregnant or breastfeeding or plan to become pregnant or breastfeed

For more information about ALOXI, talk to your doctor or see full prescribing information (click here).

ALOXI is available by prescription only.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

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