About ALOXI®: Preventing Chemotherapy-Induced Nausea and Vomiting
ALOXI® (palonosetron HCI injection) is an anti-nausea medication
also known as an antiemetic. In adults, ALOXI is used to help prevent symptoms
of chemotherapy-induced nausea
and vomiting (CINV) in a single intravenous (IV) dose by blocking the effects
of serotonin.
Depending on the type of chemotherapy you get, your chance of experiencing CINV
on the same day, known as acute CINV, can be very high. You may also experience
delayed CINV in the days following your treatment. ALOXI is used to prevent both
acute and delayed
CINV in patients receiving moderately emetogenic chemotherapy and acute CINV in patients receiving highly emetogenic chemotherapy.
If you experience CINV during one chemotherapy cycle, you are more likely to experience
CINV again during a later cycle. It is important to try to prevent these symptoms
before they start.
Powerful CINV prevention in a single dose
ALOXI is given as a single intravenous (IV) injection administered by a health care
professional about 30 minutes before the start of chemotherapy treatment. The single
ALOXI injection is likely to be given through the same IV line as your chemotherapy.
From the first cycle, ALOXI can help prevent nausea and vomiting for:
- One day following chemotherapy that is highly likely to cause nausea and vomiting
- Up to five days following chemotherapy that is moderately likely to cause nausea
and vomiting
Your doctor or nurse will help you determine if using ALOXI should be part of your
chemotherapy-induced nausea and vomiting prevention plan. Talk to your doctor and
do not take ALOXI if you are allergic to any of its ingredients. The ingredients
in ALOXI are:
Active ingredient: Palonosetron hydrochloride
Inactive ingredients: mannitol, disodium edetate, and citrate buffer
in water
The safety and effectiveness of ALOXI in children under 18 years of age have not
been established.
Potential side effects of ALOXI include headache and constipation. For a complete
list of side effects Please read the Full Product Information and discuss it with your doctor
or health care professional.
Indication
ALOXI injection is used in adults to help prevent nausea and vomiting on the day
of chemotherapy that is highly likely to cause nausea and vomiting, and up to 5
days following chemotherapy that is moderately likely to cause nausea and vomiting.
Important Safety Information
- Tell your healthcare professional if you are taking other medications or if you
are pregnant or breastfeeding
- The most common side effects of ALOXI® for
the prevention of CINV are headache and constipation
Please read the Full Product Information and discuss it with your doctor or
health care professional.
You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit http://www.FDA.gov/medwatch
or call 1-800-FDA-1088.