Delayed Nausea and Vomiting

Important Safety Information Full Prescribing Information

Delayed Nausea & Vomiting

Delayed CINV occurs more than 24 hours after chemotherapy is administered.¹

This second phase of CINV is more likely to occur in patients receiving high-dose chemotherapy regimens, in patients who have experienced acute nausea and vomiting with chemotherapy, in females, in patients who drink little or no alcohol, and in patients less than 50 years of age.²

Antiemetic therapy may be given alone or in combination to patients who are receiving chemotherapy.³

Indication

In adults, ALOXI^® (palonosetron HCl) injection 0.25 mg is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of moderately emetogenic chemotherapy, and acute nausea and vomiting associated with initial and repeat courses of highly emetogenic chemotherapy.

Important Safety Information

Aloxi is contraindicated in patients known to have hypersensitivity to the drug of any of its components
Most commonly reported adverse reactions in chemotherapy-induced nausea and vomiting include headache (9%) and constipation (5%)

For more information about ALOXI, please see Full Prescribing Information

References

Roila F., et al. Daily challenges in oncology practice. What do we need to know about antiemetics? Annals of Oncology. 2006;17(Supplement 10):x90-x94.
National Cancer Institute. Nausea and Vomiting (PDQ) Causes. Available at: http://www.cancer.gov/cancertopics/pdq/supportivecare/nausea/Patient/page3. Accessed July 7, 2010.
National Cancer Institute. Nausea and Vomiting (PDQ) Treatment. Available at: http://www.cancer.gov/cancertopics/pdq/supportivecare/nausea/Patient/page4. Accessed July 7, 2010.

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